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Dr Gina Galli

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Senior lecturer in Physiology
(Associate Professor)

gina.galli@manchester.ac.uk
 

The University of Manchester,

Biology, Medicine and Health,

Cardiovascular Sciences,

3.16a Core Technology Facility,

46 Grafton St,

Manchester, M139NT, UK

My lab is broadly focussed on the physiology of the vertebrate cardiovascular system.  We utilise a variety of animal models to understand the cellular and molecular mechanisms that drive cardiovascular disease, with a special focus on cardiac conditions that involve oxygen deprivation (hypoxia).  In particular, our team is very interested in fetal hypoxia, and the mechanisms that lead to the programming of cardiovascular disease during early development.

In addition to studying cellular function in hypoxia-sensitive mammals, we utilise a comparative approach by considering species that have naturally evolved hypoxia tolerance.  Remarkably, some ectothermic organisms, such as freshwater turtles, have successfully exploited hypoxic environments and can survive in the complete absence of oxygen for hours, days and even months.  The fact that the hearts of these species continue to beat without oxygen has far reaching, clinical implications.  Studying them may lead to the development of novel drug targets for the treatment of human oxygen-related diseases of the heart.  

Our research is generously supported by The British Heart Foundation and the Biotechnology and Biological Sciences Research Council

Current Lab Members

Dr Kerri Smith

Dr Kerri Smith

BHF Post-doctoral associate

My research aims to understand the cellular and molecular mechanisms that programme cardiovascular disease. Specifically, I am interested in the role of the mitochondria in programming cardiac dysfunction in offspring that experienced hypoxia during fetal development.

Yutong Chen

Yutong Chen

BBSRC PhD student

Research Interest: Effects of in vitro fertilisation culture conditions on cardiovascular health

Henrietha Chukwuefe

Henrietha Chukwuefe

Commonwealth PhD student

Research Interest: Effects of in vitro fertilisation culture conditions on cardiovascular health

Hayat Baba

Hayat Baba

PhD student sponsored by a Saudi Arabian government scholarship

Research Interest:
Developmental programming of cardiovascular disease

Dr Agnieszka Swiderska

Dr Agnieszka Swiderska

BHF Post-doctoral associate

Research Interest: Carotid body in health and disease

Zarin Gias

Zarin Gias

PhD student sponsored by Bangladesh government scholarship

Research Interest: Developmental programming of cardiovascular disease

Farah Hussein

Farah Hussein

BHF PhD student

Research Interest: Effects of early embryonic conditions on cardiovascular health

Ewan Camplisson

Ewan Camplisson

BBSRC PhD student

Research Interest:
Mechanisms of longevity in Greenland sharks

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