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The effects of smoking on whisker movements: A quantitative measure of exploratory behavior in rodents

Grant, RA, Cielen, N, Maes, K, Heulens, N, Galli, GLJ, Janssens, W, Gayan-Ramirez, G, Degens, H (2016): Behav. Process. 128: 17�23

Click for Abstract : Nicotine, an important component of cigarette smoke, is a�neurotransmitter�that contributes to stress, depression and anxiety in smokers. In rodents, it increases anxiety and reduces exploratory�behaviours. However, so far, the measurements of exploratory behaviour in rodents have only been semi-quantitative and lacking in sufficient detail to characterise the temporal effect of smoking cessation. As rodents, such as�mice�and�rats, primarily use whiskers to explore their environment, we studied the effect of 3 months smoking with 1 and 2 weeks smoking cessation on whisker movements in mice, using high-speed video camera footage and image analysis. Both protraction and retraction whisker velocities were increased in smoking mice (p�<�0.001) and returned to normal following just one week of smoking cessation. In addition, locomotion speeds were decreased in smoking mice, and returned to normal following smoking cessation. Lung function was also impacted by smoking and remained impaired even following smoking cessation. We suggest that the increased whisker velocities in the smoking mice reflect reduced exploration and impeded tactile performance. The increase in whisker velocity with smoking, and its reduction following smoking cessation, also lends support to�acetylcholine�being involved in awareness, attention and alertness pathways. It also shows that smoking-induced behavioural changes can be reversed with smoking cessation, which may have implications for human smokers.

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